Daphnia's "best" model organism genome for homology. Fruitfly, Mouse, Human and other well studied genomes offer useful homology/orthology evidence for Daphnia. Which may be best? MOD Gene Ontology evidence codes, and Daphnia homology In Daphnia Daphnia Daphnia Daphnia GO-Experimental/Computed N (MOD%) Unique "Best" bitscore Mouse: 10475 / 16344 10522 (55.5%) 1297 1743 135 Human: 8647 / 29989 12429 (55.9%) na na 137 Fruitfly: 3898 / 8818 7965 (59.1%) 1648 2282 146 Zebrafish: 998 / 12150 15172 (64.5%) na na 132 Worm: 6850 / 20247 6453 (32.6%) na 547 117 Yeast: 5582 / 1601 2244 (38.8%) na 97 118 ------------------------------------------------------------------ GO Computed genes have only these evidence codes (IEA|ISS|NAS|ND|NR) "In Daphnia" is MOD gene with tBLASTn e-value < 1e-10. Daphnia Unique is MOD gene count with no other organism match. Daphnia Best is MOD gene count where match is notably better than others. Insects fruitfly, mosquito and bee show similar gene homology score. Daphnia compu-genes with 2+ MOD organisms: 15,883 Daphnia compu-genes with no MOD gene but EST match: 6,376 See also this summary of model genes found: http://wfleabase.org/prerelease/summaries/daphnia-foundgenes-aug06.html The insect genes are more closely related to Daphnia than the vertebrates. So Fruitfly is a good model choice from a homology perspective. However flies have fewer known genes to match; in fact I've found evidence for a 1000 Daphnia genes hiding in the uncharacterized Fruitfly genome. Mouse is a good model organism whose experimentally determined gene functions are of stronger value than human genes. Mouse and human genes are fairly closely paired in number, homology to each other, and homology to Daphnia. Of human and mouse gene names, 13,000 are the same, 3000 are different. Zebrafish has the most matching genes. It is a model organism with growing experimental data on gene function, although it trails the others in this now. -- Don Gilbert, 2007 March